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Abstract

The Annona genus contains some species used in Mexican traditional medicine for the treatment cancer, including Annona macroprophyllata (A. macroprophyllata). The present study aimed to investigate the anticancer activity of caryophyllene oxide (CO) isolated from A. macroprophyllata using in vivo, in vitro, and in silico approaches. The identification of CO was performed using gas chromatography-mass spectroscopy and NMR methods. Antilymphoma activity was evaluated in male and female Balb/c mice inoculated with U-937 cells. Cytotoxic activity was evaluated using the WST method and flow cytometry was used to determine the type of cell death. Acute oral toxicity was determined, and a molecular docking study was performed using target proteins associated with cancer, including, HMG-CoA, Bcl-2, Mcl-1, and VEGFR-2. Results showed that CO exhibited significant antilymphoma and cytotoxic activities, and its effects were comparable to MTX. In addition, flow cytometry showed that the anticancer activity of CO could be mediated by the induction of late apoptosis and necrosis. The result for the acute oral toxicity of CO was classified in category 4, suggesting it is low risk. Finally, molecular coupling studies showed that CO had more affinity for the enzymes HMG-CoA reduc

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EAS Journal of Nutrition and Food Sciences
Volume-2-Issue-05

ABSTRACT
Worms, grubs, insects and insects larvae are traditionally important foods and tasty treats for many cultures and individuals around the world and are gaining popularity for their high nutritional values. Their potential is seriously being considered in food security and poverty alleviation strategies in many communities around the world. The nutritional and economic potentials of these abundant creature are yet to be fully realized and tapped especially in the face of climate change. Varies coleoptera is one of the grub worms commonly found in animal dung. The study was aimed at evaluating the nutrient composition of V.coleoptera and to unveil its potential as a strategy to mitigate nutritional and food insecurity. Live grub worms were hand-picked from animal dung dumps in the months of July/August. They were washed, gut squeezed out, boiled in saltwater for three minutes, set out to dry and rusted in an oven at 60oC for ten minutes. The processed sample was analyzed for its proximate nutrient content, amino acid, fatty acid and mineral element profiles using standard procedures. Proximate composition showed that processed ready-toeat V.coleoptera contains 49.2% crude protein, 26.34% crude fat, 19.2% Nit